Emergency Cases Treated with Investigational phage bank
When seeking expanded access to any investigational medical product, it is critical that the patient and his/her treating physician consider all possible risks. Investigational medical products, by definition, have not yet been evaluated for safety or effectiveness by the FDA and have not yet been approved. An investigational medical product may cause unexpected side effects, some of which could be serious. Additional information regarding expanded access can be found at the FDA.
The following expanded access case studies are provided in the spirit of dissemination and exchange of scientific information concerning APT’s investigational phage bank therapy. The administration of APT's phage bank for these cases was not within a carefully controlled clinical trial and therefore the results cannot be construed as validation of APT's phage bank's safety or efficacy.
This information was last updated October 6, 2022.
Total cases: 43
Pathogens: 10 (5 polymicrobial infections)
Infection Types: 13
Bacterial Species | Cases |
---|---|
Achromobacter xylosoxidans | 2 |
Acinetobacter baumannii | 17 |
Burkholderia cenocepacia | 1 |
Burkholderia dolosa | 1 |
Burkholderia gladioli | 1 |
Escherichia coli | 2 |
Klebsiella pneumoniae | 6 |
Pseudomonas aeruginosa | 11 |
Staphylococcus aureus | 7 |
Staphylococcus epidermidis | 1 |
Infection Type | Cases |
---|---|
Bacteremia | 2 |
Central Nervous System Infection | 1 |
Graft Infection | 1 |
Intra-abdominal infection | 1 |
Lung infection | 16 |
LVAD Infection | 3 |
Mastoiditis | 2 |
Osteomyelitis | 4 |
Prosthetic joint infection | 9 |
Sinus Infection | 1 |
Surgical site infection | 1 |
Urinary Tract Infection | 2 |
Wound infection | 7 |
Prosthetic joint infection
Patient | 43 |
---|---|
Age | 63 |
Gender | Female |
Year | 2021 |
Phage Route | IA, IV |
Pathogen | Staphylococcus aureus |
Surgical site infection
Jerusalem, Israel
Patient | 42 |
---|---|
Age | 41 |
Gender | Female |
Year | 2021 |
Phage Route | IV |
Pathogen | Pseudomonas aeruginosa |
Osteomyelitis
Baltimore, MD
Patient | 41 |
---|---|
Age | 25 |
Gender | Male |
Year | 2021 |
Phage Route | IA |
Pathogen | Pseudomonas aeruginosa |
Lung infection
Edinburg, TX
Patient | 40 |
---|---|
Age | 74 |
Gender | NA |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Lung infection
Edinburg, TX
Patient | 39 |
---|---|
Age | 83 |
Gender | NA |
Year | 2020 |
Phage Route | IV, Nebulizer |
Pathogen | Achromobacter xylosoxidans, Acinetobacter baumannii, Klebsiella pneumoniae |
Lung infection
Edinburg, TX
Patient | 38 |
---|---|
Age | 89 |
Gender | NA |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Lung infection
Wound infection
Edinburg, TX
Patient | 37 |
---|---|
Age | 52 |
Gender | NA |
Year | 2020 |
Phage Route | IV, Nebulizer |
Pathogen | Acinetobacter baumannii, Pseudomonas aeruginosa |
Lung infection
Edinburg, TX
Patient | 36 |
---|---|
Age | 66 |
Gender | NA |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Lung infection
Wound infection
Edinburg, TX
Patient | 35 |
---|---|
Age | 84 |
Gender | Not Specified |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Wound infection
Edinburg, TX
Patient | 34 |
---|---|
Age | 45 |
Gender | Not Specified |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii, Klebsiella pneumoniae |
Lung infection
Edinburg, TX
Patient | 33 |
---|---|
Age | 57 |
Gender | Not Specified |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Lung infection
Edinburg, TX
Patient | 32 |
---|---|
Age | 54 |
Gender | Not Specified |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Lung infection
Edinburg, TX
Patient | 31 |
---|---|
Age | 60 |
Gender | Not Specified |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Lung infection
Edinburg, TX
Patient | 30 |
---|---|
Age | 84 |
Gender | Not Specified |
Year | 2020 |
Phage Route | |
Pathogen | Acinetobacter baumannii |
Lung infection
Edinburg, TX
Patient | 29 |
---|---|
Age | 61 |
Gender | Female |
Year | 2020 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Prosthetic joint infection
Wound infection
Rochester, MN
Patient | 28 |
---|---|
Age | 58 |
Gender | Male |
Year | 2020 |
Phage Route | Intraoperative, IV |
Pathogen | Staphylococcus aureus |
Mastoiditis
Sinus Infection
Birmingham, AL
Patient | 27 |
---|---|
Age | 61 |
Gender | Female |
Year | 2020 |
Phage Route | IV, Topical |
Pathogen | Staphylococcus aureus |
Prosthetic joint infection
Rochester, MN
Patient | 26 |
---|---|
Age | 60 |
Gender | Male |
Year | 2020 |
Phage Route | IA, IV |
Pathogen | Staphylococcus aureus |
Prosthetic joint infection
Rochester, MN
Patient | 25 |
---|---|
Age | 61 |
Gender | Male |
Year | 2020 |
Phage Route | IA, IV |
Pathogen | Staphylococcus epidermidis |
Prosthetic joint infection
Rochester, MN
Patient | 24 |
---|---|
Age | 34 |
Gender | Female |
Year | 2020 |
Phage Route | IA |
Pathogen | Staphylococcus aureus |
Graft Infection
Bronx, NY
Patient | 23 |
---|---|
Age | 73 |
Gender | Male |
Year | 2020 |
Phage Route | IV |
Pathogen | Klebsiella pneumoniae |
LVAD Infection
Prosthetic joint infection
Columbia, SC
Patient | 22 |
---|---|
Age | 69 |
Gender | Female |
Year | 2020 |
Phage Route | IV |
Pathogen | Pseudomonas aeruginosa |
Mastoiditis
Jerusalem, Israel
Patient | 21 |
---|---|
Age | 69 |
Gender | Male |
Year | 2020 |
Phage Route | IV |
Pathogen | Pseudomonas aeruginosa |
LVAD Infection
Jerusalem, Israel
Patient | 20 |
---|---|
Age | 10 |
Gender | Female |
Year | 2019 |
Phage Route | |
Pathogen | Pseudomonas aeruginosa |
Osteomyelitis
Sydney, Australia
Patient | 19 |
---|---|
Age | 7 |
Gender | Female |
Year | 2019 |
Phage Route | IV |
Pathogen | Pseudomonas aeruginosa |
Prosthetic joint infection
Baltimore, MD
Patient | 18 |
---|---|
Age | 71 |
Gender | Male |
Year | 2019 |
Phage Route | IA, IV |
Pathogen | Staphylococcus aureus |
Prosthetic joint infection
San Diego, CA
Patient | 17 |
---|---|
Age | 61 |
Gender | Female |
Year | 2019 |
Phage Route | IA, IV |
Pathogen | Staphylococcus aureus |
Wound infection
Baltimore, MD
Patient | 16 |
---|---|
Age | 45 |
Gender | Female |
Year | 2019 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii, Klebsiella pneumoniae |
Osteomyelitis
Jerusalem, Israel
Patient | 15 |
---|---|
Age | 46 |
Gender | Male |
Year | 2019 |
Phage Route | IV |
Pathogen | Pseudomonas aeruginosa |
Prosthetic joint infection
Rochester, MN
Patient | 14 |
---|---|
Age | 61 |
Gender | Male |
Year | 2019 |
Phage Route | IV |
Pathogen | Klebsiella pneumoniae |
Lung infection
Columbia, SC
Patient | 13 |
---|---|
Age | 10 |
Gender | Female |
Year | 2019 |
Phage Route | IV |
Pathogen | Achromobacter xylosoxidans |
Urinary Tract Infection
Syracuse, NY
Patient | 12 |
---|---|
Age | 36 |
Gender | Male |
Year | 2019 |
Phage Route | Intravesicular, IV |
Pathogen | Escherichia coli |
Lung infection
Wound infection
Harefield, UK
Patient | 11 |
---|---|
Age | 23 |
Gender | Male |
Year | 2018 |
Phage Route | IV |
Pathogen | Burkholderia gladioli |
Central Nervous System Infection
Rotterdam, Netheralands
Patient | 10 |
---|---|
Age | 47 |
Gender | Male |
Year | 2018 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Bacteremia
Urinary Tract Infection
Columbia, SC
Patient | 9 |
---|---|
Age | 18 |
Gender | Female |
Year | 2018 |
Phage Route | IV |
Pathogen | Escherichia coli |
Lung infection
Cleveland, OH
Patient | 8 |
---|---|
Age | 28 |
Gender | Female |
Year | 2018 |
Phage Route | IV |
Pathogen | Burkholderia dolosa |
Osteomyelitis
Jerusalem, Israel
Patient | 7 |
---|---|
Age | 41 |
Gender | Male |
Year | 2018 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii, Klebsiella pneumoniae |
LVAD Infection
San Diego, CA
Patient | 6 |
---|---|
Age | 60 |
Gender | Male |
Year | 2017 |
Phage Route | IV |
Pathogen | Pseudomonas aeruginosa |
Lung infection
Pittsburgh, PA
Patient | 5 |
---|---|
Age | 25 |
Gender | Female |
Year | 2017 |
Phage Route | IV |
Pathogen | Burkholderia cenocepacia |
Lung infection
San Diego, CA
Patient | 4 |
---|---|
Age | 67 |
Gender | Male |
Year | 2017 |
Phage Route | IV, Nebulizer |
Pathogen | Pseudomonas aeruginosa |
Wound infection
San Diego, CA
Patient | 3 |
---|---|
Age | 77 |
Gender | Male |
Year | 2017 |
Phage Route | IV |
Pathogen | Acinetobacter baumannii |
Bacteremia
Washington, DC
Patient | 2 |
---|---|
Age | 2 |
Gender | Male |
Year | 2017 |
Phage Route | IV |
Pathogen | Pseudomonas aeruginosa |
Intra-abdominal infection
San Diego, CA
Patient | 1 |
---|---|
Age | 68 |
Gender | Male |
Year | 2017 |
Phage Route | IV, Percutaneous |
Pathogen | Acinetobacter baumannii |