Emergency Cases Treated with Investigational phage bank

When seeking expanded access to any investigational medical product, it is critical that the patient and his/her treating physician consider all possible risks. Investigational medical products, by definition, have not yet been evaluated for safety or effectiveness by the FDA and have not yet been approved. An investigational medical product may cause unexpected side effects, some of which could be serious. Additional information regarding expanded access can be found at the FDA.

The following expanded access case studies are provided in the spirit of dissemination and exchange of scientific information concerning APT’s investigational phage bank therapy. The administration of APT's phage bank for these cases was not within a carefully controlled clinical trial and therefore the results cannot be construed as validation of APT's phage bank's safety or efficacy.

This information was last updated July 13, 2023.

Total cases: 53

Pathogens: 12 (6 polymicrobial infections)

Infection Types: 15

Bacterial SpeciesCases
Achromobacter xylosoxidans2
Acinetobacter baumannii17
Burkholderia cenocepacia1
Burkholderia dolosa1
Burkholderia gladioli1
Escherichia coli2
Klebsiella pneumoniae6
MRSA1
Pseudomonas aeruginosa18
Staphylococcus aureus9
Staphylococcus epidermidis1
Staphylococcus lugdunensis1
Infection TypeCases
Bacteremia2
Central Nervous System Infection1
COVID PNA/ARDS/Recur Lt PTX/ALL remission1
Graft Infection1
Intra-abdominal infection1
Lung infection16
LVAD Infection4
Mastoiditis2
Osteomyelitis6
Otitis media1
Prosthetic joint infection13
Sinus Infection1
Surgical site infection1
Urinary Tract Infection2
Wound infection7

Case details

Patient 53

Osteomyelitis

Jerusalem, Israel

Age33
GenderMale
Year2021
Pathogen Pseudomonas aeruginosa
Patient 52

Jerusalem, Israel

Age70
GenderFemale
Year2021
Pathogen Staphylococcus aureus
Patient 51

Osteomyelitis

San Diego, CA

Age43
GenderFemale
Year2021
Pathogen Pseudomonas aeruginosa
Patient 50

LVAD Infection

Rochester, NY

Age29
GenderMale
Year2022
Pathogen MRSA, Pseudomonas aeruginosa
Patient 49

Otitis media

Dallas, TX

Age37
GenderFemale
Year2021
Pathogen Pseudomonas aeruginosa
Patient 48

Prosthetic joint infection

Rochester, MN

Age78
GenderFemale
Year2021
Pathogen Staphylococcus lugdunensis
Patient 47

Prosthetic joint infection

Jerusalem, Israel

Age64
GenderFemale
Year2022
Pathogen Staphylococcus aureus
Patient 46

Prosthetic joint infection

Pittsburgh, PA

Age95
GenderMale
Year2022
Pathogen Pseudomonas aeruginosa
Patient 45

Prosthetic joint infection

Birmingham, AL

Age76
GenderFemale
Year2021
Pathogen Pseudomonas aeruginosa
Patient 44

COVID PNA/ARDS/Recur Lt PTX/ALL remission

Marietta, GA

Age45
GenderMale
Year2021
Pathogen Pseudomonas aeruginosa
Patient 43

Prosthetic joint infection

Age63
GenderFemale
Year2021
Phage Route IA, IV
Pathogen Staphylococcus aureus
Patient 42

Surgical site infection

Jerusalem, Israel

Age41
GenderFemale
Year2021
Phage Route IV
Pathogen Pseudomonas aeruginosa
Patient 41

Osteomyelitis

Baltimore, MD

Age25
GenderMale
Year2021
Phage Route IA
Pathogen Pseudomonas aeruginosa
Patient 40

Lung infection

Edinburg, TX

Age74
GenderNA
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 39

Lung infection

Edinburg, TX

Age83
GenderNA
Year2020
Phage Route IV, Nebulizer
Pathogen Achromobacter xylosoxidans, Acinetobacter baumannii, Klebsiella pneumoniae
Patient 38

Lung infection

Edinburg, TX

Age89
GenderNA
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 37

Lung infection

Wound infection

Edinburg, TX

Age52
GenderNA
Year2020
Phage Route IV, Nebulizer
Pathogen Acinetobacter baumannii, Pseudomonas aeruginosa
Publications

Rao et al, 2022

Patient 36

Lung infection

Edinburg, TX

Age66
GenderNA
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 35

Lung infection

Wound infection

Edinburg, TX

Age84
GenderNot Specified
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 34

Wound infection

Edinburg, TX

Age45
GenderNot Specified
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii, Klebsiella pneumoniae
Patient 33

Lung infection

Edinburg, TX

Age57
GenderNot Specified
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 32

Lung infection

Edinburg, TX

Age54
GenderNot Specified
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 31

Lung infection

Edinburg, TX

Age60
GenderNot Specified
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 30

Lung infection

Edinburg, TX

Age84
GenderNot Specified
Year2020
Pathogen Acinetobacter baumannii
Patient 29

Lung infection

Edinburg, TX

Age61
GenderFemale
Year2020
Phage Route IV
Pathogen Acinetobacter baumannii
Patient 28

Prosthetic joint infection

Wound infection

Rochester, MN

Age58
GenderMale
Year2020
Phage Route Intraoperative, IV
Pathogen Staphylococcus aureus
Patient 27

Mastoiditis

Sinus Infection

Birmingham, AL

Age61
GenderFemale
Year2020
Phage Route IV, Topical
Pathogen Staphylococcus aureus
Patient 26

Prosthetic joint infection

Rochester, MN

Age60
GenderMale
Year2020
Phage Route IA, IV
Pathogen Staphylococcus aureus
Patient 25

Prosthetic joint infection

Rochester, MN

Age61
GenderMale
Year2020
Phage Route IA, IV
Pathogen Staphylococcus epidermidis
Patient 24

Prosthetic joint infection

Rochester, MN

Age34
GenderFemale
Year2020
Phage Route IA
Pathogen Staphylococcus aureus
Patient 23

Graft Infection

Bronx, NY

Age73
GenderMale
Year2020
Phage Route IV
Pathogen Klebsiella pneumoniae
Patient 22

LVAD Infection

Prosthetic joint infection

Columbia, SC

Age69
GenderFemale
Year2020
Phage Route IV
Pathogen Pseudomonas aeruginosa
Patient 21

Mastoiditis

Jerusalem, Israel

Age69
GenderMale
Year2020
Phage Route IV
Pathogen Pseudomonas aeruginosa
Patient 20

LVAD Infection

Jerusalem, Israel

Age10
GenderFemale
Year2019
Pathogen Pseudomonas aeruginosa
Patient 19

Osteomyelitis

Sydney, Australia

Age7
GenderFemale
Year2019
Phage Route IV
Pathogen Pseudomonas aeruginosa
Publications

Khatami et al, 2021

Patient 18

Prosthetic joint infection

Baltimore, MD

Age71
GenderMale
Year2019
Phage Route IA, IV
Pathogen Staphylococcus aureus
Publications

Doub et al, 2020

Patient 17

Prosthetic joint infection

San Diego, CA

Age61
GenderFemale
Year2019
Phage Route IA, IV
Pathogen Staphylococcus aureus
Patient 16

Wound infection

Baltimore, MD

Age45
GenderFemale
Year2019
Phage Route IV
Pathogen Acinetobacter baumannii, Klebsiella pneumoniae
Patient 15

Osteomyelitis

Jerusalem, Israel

Age46
GenderMale
Year2019
Phage Route IV
Pathogen Pseudomonas aeruginosa
Patient 14

Prosthetic joint infection

Rochester, MN

Age61
GenderMale
Year2019
Phage Route IV
Pathogen Klebsiella pneumoniae
Publications

Suh et al, 2020

Patient 12

Urinary Tract Infection

Syracuse, NY

Age36
GenderMale
Year2019
Phage Route Intravesicular, IV
Pathogen Escherichia coli
Publications

Duplessis et al, 2019

Patient 11

Lung infection

Wound infection

Harefield, UK

Age23
GenderMale
Year2018
Phage Route IV
Pathogen Burkholderia gladioli
Publications

Duplessis et al, 2019

Patient 10

Central Nervous System Infection

Rotterdam, Netheralands

Age47
GenderMale
Year2018
Phage Route IV
Pathogen Acinetobacter baumannii
Publications

Duplessis et al, 2019

Patient 6

LVAD Infection

San Diego, CA

Age60
GenderMale
Year2017
Phage Route IV
Pathogen Pseudomonas aeruginosa
Publications

Duplessis et al, 2019

Patient 5

Lung infection

Pittsburgh, PA

Age25
GenderFemale
Year2017
Phage Route IV
Pathogen Burkholderia cenocepacia
Publications

Duplessis et al, 2019